Patricia Casino Lab
Department of Biochemistry and Molecular Biology
Structural Biology to understand Protein Function
Structural and functional insights underlying recognition of histidine phosphotransfer protein in fungal phosphorelay systems.
Paredes-Martínez F, Eixerés L, Zamora-Caballero S, Casino P*.
Commun Biol. 2024 Jul 4;7(1):814. doi: 10.1038/s42003-024-06459-0.
Biochemical and Structural Characterization of a Novel Psychrophilic Laccase (Multicopper Oxidase) Discovered from Oenococcus oeni 229 (ENOLAB 4002)
Olmeda I, Paredes-Martínez F, Sendra R, Casino P*, Pardo I*, Ferrer S.
Int J Mol Sci. 2024 Aug 5;25(15):8521. doi: 10.3390/ijms25158521.
Evolutionary analysis and structure modelling of the Rcs-repressor IgaA unveil a functional role of two cytoplasmic small β-barrel (SBB) domains.
Rodríguez L, Peñalver M, Casino P, García-Del Portillo F*.
Heliyon. 2023 May 26;9(6):e16661. doi: 10.1016/j.heliyon.2023.e16661.
Structural and functional role of Domain I for the insecticidal activity of the Vip3Aa protein from Bacillus thuringiensis.
Lázaro-Berenguer M, Paredes-Martínez F, Bel Y, Núñez-Ramírez R, Arias-Palomo E, Casino P*, Ferré J*.
Microb Biotechnol. 2022 Oct;15(10):2607-2618. doi: 10.1111/1751-7915.14110.
Lateral Flow Microimmunoassay (LFµIA) for the Reliable Quantification of Allergen Traces in Food Consumables.
Sena-Torralba A, Gabaldón-Atienza J, Cubells-Gómez A, Casino P, Maquieira Á, Morais S
Biosensors (Basel). 2022 Nov 7;12(11):980. doi: 10.3390/bios12110980.
An ultra-sensitive homologous chemiluminescence immunoassay to tackle penicillin allergy.
Quintero-Campos P, Segovia-de Los Santos P, Ibáñez-Echevarria E, Hernández-Fernández de Rojas D, Casino P, Lassabe G, González-Sapienza G, Maquieira Á, Morais S.
Anal Chim Acta. 2022 Jun 29;1214:339940. doi: 10.1016/j.aca.2022.339940.
Structure-based analyses of Salmonella RcsB variants unravel new features of the Rcs regulon
Huesa J, Giner-Lamia J, Pucciarelli MG, Paredes-Martínez F, García-del Portillo F*, Marina A*, Casino P*
Nucleic Acids Res. 2021 Feb 26;49(4):2357-2374. doi: 10.1093/nar/gkab060.
Structural analysis and biochemical properties of laccase enzymes from two Pediococcus species.
Olmeda I, Casino P, Collins RE, Sendra R, Callejón S, Huesa J, Soares AS, Ferrer S, Pardo I.
Microb Biotechnol. 2021 May;14(3):1026-1043. doi: 10.1111/1751-7915.13751.
Structural and Functional Characterization of Autophosphorylation in Bacterial Histidine Kinases.
Miguel-Romero L, Mideros-Mora C, Marina A*, Casino P*.
Methods Mol Biol. 2020;2077:121-140. doi: 10.1007/978-1-4939-9884-5_9.
Molecular architecture and activation of the insecticidal protein Vip3Aa from Bacillus thuringiensis.
Núñez-Ramírez R, Huesa J, Bel Y, Ferré J, Casino P*, Arias-Palomo E*.
Nat Commun. 2020 Aug 7;11(1):3974. doi: 10.1038/s41467-020-17758-5.
Revisiting the pH-gated conformational switch on the activities of HisKA-family histidine kinases.
Mideros-Mora C, Miguel-Romero L, Felipe-Ruiz A, Casino P*, Marina A*.
Nat Commun. 2020 Feb 7;11(1):769. doi: 10.1038/s41467-020-14540-5. Erratum in: Nat Commun. 2020 May 19;11(1):2489.
Peptides as Versatile Platforms for Quantum Computing.
Rosaleny LE, Cardona-Serra S, Escalera-Moreno L, Baldoví JJ, GoÅ‚È©biewska V, WlazÅ‚o K, Casino P, Prima-García H, Gaita-Ariño A, Coronado E.
J Phys Chem Lett. 2018 Aug 16;9(16):4522-4526. doi: 10.1021/acs.jpclett.8b01813.
Conformational dynamism for DNA interaction in the Salmonella RcsB response regulator.
Casino P*, Miguel-Romero L, Huesa J, García P, García-Del Portillo F, Marina A*.
Nucleic Acids Res. 2018 Jan 9;46(1):456-472. doi: 10.1093/nar/gkx1164.
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly.
Casino P*, Gozalbo-Rovira R, Rodríguez-Díaz J, Banerjee S, Boutaud A, Rubio V, Hudson BG, Saus J, Cervera J, Marina A*.
IUCrJ. 2018 Oct 10;5(Pt 6):765-779. doi: 10.1107/S2052252518012459. Erratum in: IUCrJ. 2020 Jun 13;7(Pt 4):777. doi: 10.1107/S2052252520007216.
The malate sensing two-component system MaeKR is a non-canonical class of sensory complex for C4-dicarboxylates.
Miguel-Romero L, Casino P, Landete JM, Monedero V, Zúñiga M, Marina A.
Sci Rep. 2017 Jun 2;7(1):2708. doi: 10.1038/s41598-017-02900-z.
Visualizing autophosphorylation in histidine kinases.
Casino P, Miguel-Romero L, Marina A.
Nat Commun. 2014;5:3258. doi: 10.1038/ncomms4258. Erratum in: Nat Commun. 2014;5:3645. PMID: 24500224.
Structural basis of a rationally rewired protein-protein interface critical to bacterial signaling.
Podgornaia AI, Casino P, Marina A, Laub MT.
Structure. 2013 Sep 3;21(9):1636-47. doi: 10.1016/j.str.2013.07.005. Epub 2013 Aug 15. PMID: 23954504; PMCID: PMC3821218.
Structural bases of signal transduction and specificity in two components systems.
Casino P, López-Redondo M, Marina A.
Two component systems in bacteria 2012; ISBN 978-1-908230-08-9. Caister Academic Press
The mechanism of signal transduction by two-component systems.
Casino P, Rubio V, Marina A.
Curr Opin Struct Biol. 2010 Dec;20(6):763-71. doi: 10.1016/j.sbi.2010.09.010. Epub 2010 Oct 13. PMID: 20951027.
Structural insight into partner specificity and phosphoryl transfer in two-component signal transduction.
Casino P, Rubio V, Marina A.
Cell. 2009 Oct 16;139(2):325-36. doi: 10.1016/j.cell.2009.08.032. Epub 2009 Oct 1. PMID: 19800110.
Identification of a novel two component system in Thermotoga maritima. Complex stoichiometry and crystallization.
Casino P, Fernández-Alvarez A, Alfonso C, Rivas G, Marina A.
Biochim Biophys Acta. 2007 May;1774(5):603-9. doi: 10.1016/j.bbapap.2007.02.005. Epub 2007 Feb 20. PMID: 17478132.
Synthesis and characterization of allosteric probes of substrate channeling in the tryptophan synthase bienzyme complex.
Ngo H, Harris R, Kimmich N, Casino P, Niks D, Blumenstein L, Barends TR, Kulik V, Weyand M, Schlichting I, Dunn MF.
Biochemistry. 2007 Jul 3;46(26):7713-27. doi: 10.1021/bi700385f.
Allosteric regulation of tryptophan synthase channeling: the internal aldimine probed by trans-3-indole-3'-acrylate binding.
Casino P, Niks D, Ngo H, Pan P, Brzovic P, Blumenstein L, Barends TR, Schlichting I, Dunn MF.
Biochemistry. 2007 Jul 3;46(26):7728-39. doi: 10.1021/bi700386b.
Proton transfers in the beta-reaction catalyzed by tryptophan synthase.
Hur O, Niks D, Casino P, Dunn MF.
Biochemistry. 2002 Aug 6;41(31):9991-10001. doi: 10.1021/bi025568u.
Assessment of enzyme-linked immunosorbent assay for the determination of 2,4,5-TP in water and soil.
Morais S, Casino P, Marín ML, Puchades R, Maquieira A.
Anal Bioanal Chem. 2002 Sep;374(2):262-8. doi: 10.1007/s00216-002-1447-z.
Evaluation of enzyme-linked immunoassays for the determinationof chlororacetanilides in water and soil.
Casino P, Morais S, Puchades R, Maquieira A.
Environ. Sci. Technol.; DOI: 10.1021/es010569f. 35, pp. 4111 - 4119. 2001.